| Peer-Reviewed

Investigation of the Medicinal Potentials of Syzygium jambos (L.) Extract and Characterization of the Isolated Compounds

Received: 23 January 2015     Accepted: 23 January 2015     Published: 27 February 2015
Views:       Downloads:
Abstract

Syzygium jambos (L.) Alstone belonging to the Myrtaceae family have been investigated for isolation of their secondary metabolites and evaluation of their biological activities. A total of three compounds have been isolated. The isolated compounds were identified by extensive analysis of their high resolution 1H-NMR spectroscopic data.The dried stem barks of Syzygium jambos was extracted with methanol. The concentrated methanolic extract was then partitioned with vacuum liquid chromatography. The first investigation was conducted with the VLC fraction-6 afforded one pentacyclic triterpenes (SJ-61), VLC fraction-9 afforded a sitosterol (SJ-92) and VLC fraction-16 afforded a triterpene 3-nor-2,3-fridelan derivative (SJ-184). In the brine shrimp lethality bioassay, The LC50 values were found to be 6.97, 18.07, 64.943, 247.596 and 12.75mg/ml for crude methanolic extract, carbon tetrachloride, chloroform and n-hexane soluble fractions of methanolic extract of Syzygium jambos respectively representing methanolic extract fraction as highly cytotoxic.

Published in American Journal of BioScience (Volume 3, Issue 2-1)

This article belongs to the Special Issue Pharmacological and Phytochemicals Investigation

DOI 10.11648/j.ajbio.s.2015030201.13
Page(s) 12-18
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Medicinal Plant, Extraction, Isolation, Characterization, Cytotoxicity, Biological Activity

References
[1] Farnsworth N.R., Akerele O., Bingel A.S., Soejarto D.D., Guo Z., 1985.Medicinal plants in therapy. Bull W H O 63: 965–981
[2] Kumar S., Kumar R., Khan A., 2011, Medicinal plant resources: manifestation and prospects of life- sustaining healthcare system, Cont. J. Biol. Sci., 4 (1): 19 – 29
[3] Hong-Fang J., Jue-Juan L., Hong-Yu Z., 2009, Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia, EMBO Rep. Mar 2009; 10(3): 194–200
[4] Ayensu E.S., DeFilipps R. A., 1978, Endangered and Threatened Plants of the United States. Washington, DC: Smithsonian Institution
[5] Cronquist A., 1988, The Evolution and Classification of Flowering Plants, Bronx, NY:New York Botanical Garden
[6] Tippo O., Stern W. L., 1977, Humanistic Botany. New York:W.W. Norton
[7] Schultes R.E., 1972, The future of plants as sources of new biodynamic compounds: Plants in the Development of Modern Medicine (Swain T, ed). Cambridge, MA:Harvard University Press, 103–124
[8] Verpoorte R., 2000. Pharmacognosy in the new millennium: lead finding and biotechnology. J Pharm Pharmacol. 52, 253-262.
[9] Burbaum J.J., Ohlmeyer M.H., Reader J.C., Henderson I, Dillard L.W., Li J., Randle T.L.,Sigal N.H., Chelsky D., Baldwin J.J., 1995, Proc Natl Acad Sci U S A, 92(13): 6027–6031
[10] Md. Reyad-Ul-Ferdous, Sayma Akhter, Md. Zahirul Islam Khan, Md. Eshak Khan, Md. Atiqul Islam, Md. Sharif Ullah. Ex-Vivo Anti-Inflammatory and Antimicrobial Activities of the Leaves of Bauhinia acuminata. American Journal of Life Sciences. Vol. 2, No. 5, 2014, pp. 267-270. doi:10.11648/j.ajls.20140205.13
[11] Reyad-ul-Ferdous M, Alam TT, Islam MA, Khan MZI, Tasnim F, et al (2014) Ex-Vivo Cardioprotective and Cytotoxic Screening of Fruits of Parmentiera ereifera Seem. Biol Med 6: 219. doi: 10.4172/0974-8369.1000219
[12] Van Wagenen B.C., Larsen R., Cardellina J.H. II, Ran dazzo D., Lidert Z.C., Swithenbank C., 1993. Ulosantoin, a potent insecticide from the sponge Ulosa ruetzleri. J. Org. Chem. 58, 335-337
[13] Meyer B.N., Ferringni N.R., Puam, J.E., Lacobsen L.B., Nichols D.E., 1982. Drug Info Journal, 31, 516-554
[14] Maclaughlin J. L., Anderson J. E., Rogers and Lingling, L., 1998, Drug Info Journal, 32: 513-524
Cite This Article
  • APA Style

    Majidul Haque, Mst. Marium Begum, Moynul Hasan, A. F. M. Towheedur Rahman, Md. Iftekhar Hussain, et al. (2015). Investigation of the Medicinal Potentials of Syzygium jambos (L.) Extract and Characterization of the Isolated Compounds. American Journal of BioScience, 3(2-1), 12-18. https://doi.org/10.11648/j.ajbio.s.2015030201.13

    Copy | Download

    ACS Style

    Majidul Haque; Mst. Marium Begum; Moynul Hasan; A. F. M. Towheedur Rahman; Md. Iftekhar Hussain, et al. Investigation of the Medicinal Potentials of Syzygium jambos (L.) Extract and Characterization of the Isolated Compounds. Am. J. BioScience 2015, 3(2-1), 12-18. doi: 10.11648/j.ajbio.s.2015030201.13

    Copy | Download

    AMA Style

    Majidul Haque, Mst. Marium Begum, Moynul Hasan, A. F. M. Towheedur Rahman, Md. Iftekhar Hussain, et al. Investigation of the Medicinal Potentials of Syzygium jambos (L.) Extract and Characterization of the Isolated Compounds. Am J BioScience. 2015;3(2-1):12-18. doi: 10.11648/j.ajbio.s.2015030201.13

    Copy | Download

  • @article{10.11648/j.ajbio.s.2015030201.13,
      author = {Majidul Haque and Mst. Marium Begum and Moynul Hasan and A. F. M. Towheedur Rahman and Md. Iftekhar Hussain and Mohammad Mizanur Rahman and Md. Hazrat Ali and Md. Ashraful Islam and Md. Zakir Sultan and Md. Reyad-ul- Ferdous and Choudhury Mahmood Hasan},
      title = {Investigation of the Medicinal Potentials of Syzygium jambos (L.) Extract and Characterization of the Isolated Compounds},
      journal = {American Journal of BioScience},
      volume = {3},
      number = {2-1},
      pages = {12-18},
      doi = {10.11648/j.ajbio.s.2015030201.13},
      url = {https://doi.org/10.11648/j.ajbio.s.2015030201.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.s.2015030201.13},
      abstract = {Syzygium jambos (L.) Alstone belonging to the Myrtaceae family have been investigated for isolation of their secondary metabolites and evaluation of their biological activities. A total of three compounds have been isolated. The isolated compounds were identified by extensive analysis of their high resolution 1H-NMR spectroscopic data.The dried stem barks of Syzygium jambos was extracted with methanol. The concentrated methanolic extract was then partitioned with vacuum liquid chromatography. The first investigation was conducted with the VLC fraction-6 afforded one pentacyclic triterpenes (SJ-61), VLC fraction-9 afforded a sitosterol (SJ-92) and VLC fraction-16 afforded a triterpene 3-nor-2,3-fridelan derivative (SJ-184). In the brine shrimp lethality bioassay, The LC50 values were found to be 6.97, 18.07, 64.943, 247.596 and 12.75mg/ml for crude methanolic extract, carbon tetrachloride, chloroform and n-hexane soluble fractions of methanolic extract of Syzygium jambos respectively representing methanolic extract fraction as highly cytotoxic.},
     year = {2015}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Investigation of the Medicinal Potentials of Syzygium jambos (L.) Extract and Characterization of the Isolated Compounds
    AU  - Majidul Haque
    AU  - Mst. Marium Begum
    AU  - Moynul Hasan
    AU  - A. F. M. Towheedur Rahman
    AU  - Md. Iftekhar Hussain
    AU  - Mohammad Mizanur Rahman
    AU  - Md. Hazrat Ali
    AU  - Md. Ashraful Islam
    AU  - Md. Zakir Sultan
    AU  - Md. Reyad-ul- Ferdous
    AU  - Choudhury Mahmood Hasan
    Y1  - 2015/02/27
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajbio.s.2015030201.13
    DO  - 10.11648/j.ajbio.s.2015030201.13
    T2  - American Journal of BioScience
    JF  - American Journal of BioScience
    JO  - American Journal of BioScience
    SP  - 12
    EP  - 18
    PB  - Science Publishing Group
    SN  - 2330-0167
    UR  - https://doi.org/10.11648/j.ajbio.s.2015030201.13
    AB  - Syzygium jambos (L.) Alstone belonging to the Myrtaceae family have been investigated for isolation of their secondary metabolites and evaluation of their biological activities. A total of three compounds have been isolated. The isolated compounds were identified by extensive analysis of their high resolution 1H-NMR spectroscopic data.The dried stem barks of Syzygium jambos was extracted with methanol. The concentrated methanolic extract was then partitioned with vacuum liquid chromatography. The first investigation was conducted with the VLC fraction-6 afforded one pentacyclic triterpenes (SJ-61), VLC fraction-9 afforded a sitosterol (SJ-92) and VLC fraction-16 afforded a triterpene 3-nor-2,3-fridelan derivative (SJ-184). In the brine shrimp lethality bioassay, The LC50 values were found to be 6.97, 18.07, 64.943, 247.596 and 12.75mg/ml for crude methanolic extract, carbon tetrachloride, chloroform and n-hexane soluble fractions of methanolic extract of Syzygium jambos respectively representing methanolic extract fraction as highly cytotoxic.
    VL  - 3
    IS  - 2-1
    ER  - 

    Copy | Download

Author Information
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

  • Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

  • Department of Pharmacy, Dhaka International University, Dhaka-1213, Bangladesh

  • Department of Pharmaceutical Sciences, North South University, Dhaka-1229, Bangladesh

  • Department of Pharmacy, Primeasia University, Dhaka-1213, Bangladesh

  • Department of Pharmacy, Primeasia University, Dhaka-1213, Bangladesh

  • Department of Pharmacy, International Islamic University, Chittagong-4203, Bangladesh

  • Department of Biomedical Imaging, Faculty of Bioscience, Abo Akademi University, Turku, Finland

  • Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000, Bangladesh

  • Department of Pharmaceutical Sciences, North South University, Dhaka-1229, Bangladesh

  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

  • Sections