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Potential In-Vivo Evaluation of Analgesic Investigation of Mangifera indica and Antimicrobial Activity of Areca catechu

Received: 9 February 2015     Accepted: 10 February 2015     Published: 27 February 2015
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Abstract

This project report describes the biological activity of the dried leaves of Mangifera indica belonging to the family Anacardiaceae and the dried fruits of Areca catechu belonging to the family Arecaceae. The dried powders of leaves and fruits were extracted with organic solvents –Carbon tetrachloride, Methanol & Pet ether sequentially by maceration process. After this, The crude extracts of Carbon tetrachloride, Methanol & Pet ether were investigated for analgesic and antimicrobial property. For Mangifera indica, the crude extracts of Carbon tetrachloride, Methanol & Pet ether were studied for analgesic property at an oral dose of 200 mg /kg of body weight using acetic acid induced writhing effect method. The result showed that the Methanol and Pet ether extracts had mild analgesic property (having a writhing inhibition of 51.7% and 50% respectively), while carbon tetrachloride extract did not show significant analgesic property (having a writhing inhibition of 30 %). For Areca catechu, the crude extracts of Carbon tetrachloride, Methanol & Pet ether were screened for antimicrobial activity against gram positive and gram negative bacteria and fungi using disk diffusion method. The results obtained were compared with that of standard drug kanamycin. The Carbon tetrachloride extract showed mild sensitivity to several gram positive, gram negative bacteria & Fungi (zone of inhibition 9-10 mm). The Methanol extract also showed mild sensitivity to several gram positive, gram negative bacteria & Fungi (zone of inhibition 7-10 mm).and slightly to highly sensitive to fungi (zone of inhibition 8-40 mm). The pet ether extract Crystal (Found after adding Carbon tetrachloride) showed mild sensitivity to only a gram negative bacteria (Shigella boydii) having zone of inhibition 7 mm.

Published in American Journal of BioScience (Volume 3, Issue 2-1)

This article belongs to the Special Issue Pharmacological and Phytochemicals Investigation

DOI 10.11648/j.ajbio.s.2015030201.14
Page(s) 19-22
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Mangifera indica, Anacardiaceae, Areca catechu Arecaceae, Antimicrobial Activity, Disc Diffusion Method, Analgesic Activity, Writhing Effect

References
[1] Ghani A. Medicinal Plants of Bangladesh. 2nd ed. The Asiatic Society of Bangladesh, 2003:1-17.
[2] A review on the pharmacology and phytochemistry of traditional medicinal plant, Glycosmis pentaphylla (Retz.) Correa, Sreejith, P. S.; Praseeja, R. J.; Asha, V. V., Journal of Pharmacy Research; 2012, Vol. 5 Issue 5, p27-23
[3] Swerdlow, J.L., 2000, Nature’s Medicine plants that Heal, National Geographic Society, Washington D.C., Usa, Page-7.
[4] Yusuf, M., Chowdhury, J. U., Wahab, M. A., Begum, J. 1994. Medicinal Plants of Bangladesh. Bangladesh Council of Scientific and Industrial Research, Dhaka 1205. Bangladesh.
[5] Bompard JM, Schnell RJ (1997) Taxonomy and Systematics. In: Litz R (Ed) The Mango, CAB International, New York, USA, pp 21-47
[6] Ghani, A (2003). Medicinal Plants of Bangladesh. The Asiatic Society of Bangladesh, Dhaka, Bangladesh, 2nd edition, pp 603.
[7] Reyad-ul-Ferdous M, Alam TT, Islam MA, Khan MZI, Tasnim F, et al (2014) Ex-Vivo Cardioprotective and Cytotoxic Screening of Fruits of Parmentiera ereifera Seem. Biol Med 6: 219. doi: 10.4172/0974-8369.1000219.
[8] Md. Reyad-Ul-Ferdous, Sayma Akhter, Md. Zahirul Islam Khan, Md. Eshak Khan, Md. Atiqul Islam, Md. Sharif Ullah. Ex-Vivo Anti-Inflammatory and Antimicrobial Activities of the Leaves of Bauhinia acuminata. American Journal of Life Sciences. Vol. 2, No. 5, 2014, pp. 267-270. doi: 10.11648/j.ajls.20140205.13.
[9] Koster R, Anderson M and de Beer EJ, 1959, Acetic acid for analgesic screening. Fed. Proc.; 18: 412.
[10] Bauer, A.W., Kirby, W.M.M., Sherris, J.C. and Truck, M,; 1966, Antibiotic susceptibilty testing by a standerdized single disc method, Am. J. Clin. Pathol. 45: 493-496.
[11] Whittle, B.A., 1964, The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesics. Br. J. Pharmacol. Chemother. 22, 246-253.
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    Mst. Marium Begum, Taslima Begum, Mohammad Ashikur Rahman, Tahmina Haque, Md. Abir Khan, et al. (2015). Potential In-Vivo Evaluation of Analgesic Investigation of Mangifera indica and Antimicrobial Activity of Areca catechu. American Journal of BioScience, 3(2-1), 19-22. https://doi.org/10.11648/j.ajbio.s.2015030201.14

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    ACS Style

    Mst. Marium Begum; Taslima Begum; Mohammad Ashikur Rahman; Tahmina Haque; Md. Abir Khan, et al. Potential In-Vivo Evaluation of Analgesic Investigation of Mangifera indica and Antimicrobial Activity of Areca catechu. Am. J. BioScience 2015, 3(2-1), 19-22. doi: 10.11648/j.ajbio.s.2015030201.14

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    AMA Style

    Mst. Marium Begum, Taslima Begum, Mohammad Ashikur Rahman, Tahmina Haque, Md. Abir Khan, et al. Potential In-Vivo Evaluation of Analgesic Investigation of Mangifera indica and Antimicrobial Activity of Areca catechu. Am J BioScience. 2015;3(2-1):19-22. doi: 10.11648/j.ajbio.s.2015030201.14

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  • @article{10.11648/j.ajbio.s.2015030201.14,
      author = {Mst. Marium Begum and Taslima Begum and Mohammad Ashikur Rahman and Tahmina Haque and Md. Abir Khan and Md. Belal Hossain and Hasan Tarek and Md. Noor-A-Alam and Md. Reyad-ul- Ferdous and Md. Safkath Ibne Jami},
      title = {Potential In-Vivo Evaluation of Analgesic Investigation of Mangifera indica and Antimicrobial Activity of Areca catechu},
      journal = {American Journal of BioScience},
      volume = {3},
      number = {2-1},
      pages = {19-22},
      doi = {10.11648/j.ajbio.s.2015030201.14},
      url = {https://doi.org/10.11648/j.ajbio.s.2015030201.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.s.2015030201.14},
      abstract = {This project report describes the biological activity of the dried leaves of Mangifera indica belonging to the family Anacardiaceae and the dried fruits of Areca catechu belonging to the family Arecaceae. The dried powders of leaves and fruits were extracted with organic solvents –Carbon tetrachloride, Methanol & Pet ether sequentially by maceration process. After this, The crude extracts of Carbon tetrachloride, Methanol & Pet ether were investigated for analgesic and antimicrobial property. For Mangifera indica, the crude extracts of Carbon tetrachloride, Methanol & Pet ether were studied for analgesic property at an oral dose of   200 mg /kg of body weight using acetic acid induced writhing effect method. The result showed that the Methanol and Pet ether extracts had mild analgesic property (having a writhing inhibition of 51.7% and 50% respectively), while carbon tetrachloride extract did not show significant analgesic property (having a writhing inhibition of 30 %). For Areca catechu, the crude extracts of Carbon tetrachloride, Methanol & Pet ether were screened for antimicrobial activity against gram positive and gram negative bacteria and fungi using disk diffusion method. The results obtained were compared with that of standard drug kanamycin. The Carbon tetrachloride extract showed mild sensitivity to several gram positive, gram negative bacteria & Fungi (zone of inhibition 9-10 mm). The Methanol extract also showed mild sensitivity to several gram positive, gram negative bacteria & Fungi (zone of inhibition 7-10 mm).and slightly to highly sensitive to fungi (zone of inhibition 8-40 mm). The pet ether extract Crystal (Found after adding Carbon tetrachloride) showed mild sensitivity to only a gram negative bacteria (Shigella boydii) having zone of inhibition 7 mm.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Potential In-Vivo Evaluation of Analgesic Investigation of Mangifera indica and Antimicrobial Activity of Areca catechu
    AU  - Mst. Marium Begum
    AU  - Taslima Begum
    AU  - Mohammad Ashikur Rahman
    AU  - Tahmina Haque
    AU  - Md. Abir Khan
    AU  - Md. Belal Hossain
    AU  - Hasan Tarek
    AU  - Md. Noor-A-Alam
    AU  - Md. Reyad-ul- Ferdous
    AU  - Md. Safkath Ibne Jami
    Y1  - 2015/02/27
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajbio.s.2015030201.14
    DO  - 10.11648/j.ajbio.s.2015030201.14
    T2  - American Journal of BioScience
    JF  - American Journal of BioScience
    JO  - American Journal of BioScience
    SP  - 19
    EP  - 22
    PB  - Science Publishing Group
    SN  - 2330-0167
    UR  - https://doi.org/10.11648/j.ajbio.s.2015030201.14
    AB  - This project report describes the biological activity of the dried leaves of Mangifera indica belonging to the family Anacardiaceae and the dried fruits of Areca catechu belonging to the family Arecaceae. The dried powders of leaves and fruits were extracted with organic solvents –Carbon tetrachloride, Methanol & Pet ether sequentially by maceration process. After this, The crude extracts of Carbon tetrachloride, Methanol & Pet ether were investigated for analgesic and antimicrobial property. For Mangifera indica, the crude extracts of Carbon tetrachloride, Methanol & Pet ether were studied for analgesic property at an oral dose of   200 mg /kg of body weight using acetic acid induced writhing effect method. The result showed that the Methanol and Pet ether extracts had mild analgesic property (having a writhing inhibition of 51.7% and 50% respectively), while carbon tetrachloride extract did not show significant analgesic property (having a writhing inhibition of 30 %). For Areca catechu, the crude extracts of Carbon tetrachloride, Methanol & Pet ether were screened for antimicrobial activity against gram positive and gram negative bacteria and fungi using disk diffusion method. The results obtained were compared with that of standard drug kanamycin. The Carbon tetrachloride extract showed mild sensitivity to several gram positive, gram negative bacteria & Fungi (zone of inhibition 9-10 mm). The Methanol extract also showed mild sensitivity to several gram positive, gram negative bacteria & Fungi (zone of inhibition 7-10 mm).and slightly to highly sensitive to fungi (zone of inhibition 8-40 mm). The pet ether extract Crystal (Found after adding Carbon tetrachloride) showed mild sensitivity to only a gram negative bacteria (Shigella boydii) having zone of inhibition 7 mm.
    VL  - 3
    IS  - 2-1
    ER  - 

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Author Information
  • Department of Pharmacy, Primeasia University, Dhaka-1213, Bangladesh

  • Department of Pharmacy, Primeasia University, Dhaka-1213, Bangladesh

  • Department of Pharmacy, Primeasia University, Dhaka-1213, Bangladesh

  • Department of Pharmacy, Primeasia University, Dhaka-1213, Bangladesh

  • Department of Pharmacy, Primeasia University, Dhaka-1213, Bangladesh

  • Department of Pharmacy, Dhaka International University, Dhaka-1213, Bangladesh

  • Department of Pharmacy, Dhaka International University, Dhaka-1213, Bangladesh

  • Department of Pharmacy, Dhaka International University, Dhaka-1213, Bangladesh

  • Department of Pharmaceutical Sciences, North South University, Dhaka-1229, Bangladesh

  • Department of Pharmacy, University of Asia Pacific, Dhaka-1205, Bangladesh

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